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    Organic Compounds and Genotoxicity in Drinking Water

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    Author(s)
    Noorsij, A.
    van Genderen, J.
    van Beveren, J.
    Language
    English
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    Abstract
    Until recently only lipophilic compounds were analysed in any research on the occurrence of mutanogenic and carcinogenic compounds in water. They were isolated using XAD-resins. They contain approximately half of the total organic material present in water. A clear mutanogenic effect was demonstrated for these compounds using Amestest. The hydrophilic fraction of the organic material was difficult to investigate because of problems with isolation and analysis caused by its high solubility. The high solubility means in practice that the hydrophilic compounds are mobile in conventional treatment systems and in soil and can easily penetrate into drinking water. A method was developed to isolate hydrophilic compounds using a combination of ion exchange and a clean-up with a XAD-resin. The isolated compounds were examined with the Amestest for the presence of mutanogenic compounds. For some tested water types a mutanogenic effect was found in the lipophilic material. Due to oxidation with ozone, mutanogenic compounds can be formed from (non-mutanogenic) industrial pollutions. No mutanogenic activity was found in the hydrophilic organic material of all examined water types, even after ozone oxidation or chlorination. It was hypothesized that hydrophilic compounds can not reach the DNA of the cell, thus they do not play any (geno) toxicological role.
    URI
    http://library.oapen.org/handle/20.500.12657/30987
    Keywords
    organic compounds genotoxicity drinking
    DOI
    10.2166/9781780402598
    Publisher
    IWA Publishing
    Publisher website
    https://www.iwapublishing.com/
    Publication date and place
    2004
    Classification
    Industrial applications of scientific research and technological innovation
    Water supply and treatment
    Rights
    All rights reserved
    • Imported or submitted locally

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    License

    • If not noted otherwise all contents are available under Attribution 4.0 International (CC BY 4.0)

    Credits

    • logo EU
    • This project received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No 683680, 810640, 871069 and 964352.

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