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    Chapter Perspectives in Glycomics and Lectin Engineering

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    Author(s)
    Tkac, Jan
    Nahalka, Jozef
    Gemeiner, Peter
    Bertok, Tomas
    Collection
    European Research Council (ERC); EU collection
    Language
    English
    Show full item record
    Abstract
    This chapter would like to provide a short survey of the most promising concepts applied recently in analysis of glycoproteins based on lectins. The first part describes the most exciting analytical approaches used in the field of glycoprofiling based on integration of nanoparticles, nanowires, nanotubes, or nanochannels or using novel transducing platforms allowing to detect very low levels of glycoproteins in a label-free mode of operation. The second part describes application of recombinant lectins containing several tags applied for oriented and ordered immobilization of lectins. Besides already established concepts of glycoprofiling several novel aspects, which we think will be taken into account for future, more robust glycan analysis, are described including modified lectins, peptide lectin aptamers, and DNA aptamers with lectin-like specificity introduced by modified nucleotides. The last part of the chapter describes a novel concept of a glycocodon, which can lead to a better understanding of glycan–lectin interaction and for design of novel lectins with unknown specificities and/or better affinities toward glycan target or for rational design of peptide lectin aptamers or DNA aptamers.
    Book
    Lectins. Methods and protocols
    URI
    http://library.oapen.org/handle/20.500.12657/32152
    Keywords
    lectins; glycomics; dna aptamers; biosensors; nanoparticles; lectin peptide aptamers; recombinant lectins; lectins; glycomics; dna aptamers; biosensors; nanoparticles; lectin peptide aptamers; recombinant lectins; Amino acid; Carbon nanotube; Glycan; Glycoprotein; Nucleotide
    DOI
    10.1007/978-1-4939-1292-6_37
    OCN
    1030815421
    Publisher
    Springer Nature
    Publisher website
    https://www.springernature.com/gp/products/books
    Publication date and place
    2014
    Grantor
    • FP7 Ideas: European Research Council - 311532 - ELENA - Electrochemical LEctin and glycan biochips in - FP7 SC39 Research grant informationFind all documents
    Classification
    Biochemistry
    Public remark
    Relevant Wikipedia pages: Amino acid - https://en.wikipedia.org/wiki/Amino_acid; Aptamer - https://en.wikipedia.org/wiki/Aptamer; Biosensor - https://en.wikipedia.org/wiki/Biosensor; Carbon nanotube - https://en.wikipedia.org/wiki/Carbon_nanotube; DNA - https://en.wikipedia.org/wiki/DNA; Glycan - https://en.wikipedia.org/wiki/Glycan; Glycomics - https://en.wikipedia.org/wiki/Glycomics; Glycoprotein - https://en.wikipedia.org/wiki/Glycoprotein; Lectin - https://en.wikipedia.org/wiki/Lectin; Nucleotide - https://en.wikipedia.org/wiki/Nucleotide
    Rights
    All rights reserved
    • Imported or submitted locally

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    • If not noted otherwise all contents are available under Attribution 4.0 International (CC BY 4.0)

    Credits

    • logo EU
    • This project received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No 683680, 810640, 871069 and 964352.

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