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    Chapter 3 Xenotropic Murine Leukemia Virus-Related Virus as a Case Study: Using a Precautionary Risk Management Approach for Emerging Blood-Borne Pathogens in Canada

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    Author(s)
    Oraby, Tamer
    Aspinall, Willy
    Wu, Jun
    ElSaadany, Susie
    Tyshenko, Michael G.
    Ganz, Peter R.
    Laderoute, Marian
    Krewski, Daniel
    Collection
    European Research Council (ERC)
    Language
    English
    Show full item record
    Abstract
    In October 2009 it was reported that 68 of 101 patients with chronic fatigue syndrome (CFS) in the United States, when tested, were infected with a novel gamma retrovirus, xenotropic murine leukemia virus-related virus (XMRV) (Lombardi et al., 2009). XMRV is a recently discovered human gammaretrovirus first described in prostate cancers that shares significant homology with murine leukemia virus (MLV) (Ursiman et al., 2006). It is known that XMRV can cause leukemias and sarcomas in several rodent, feline, and primate species but has not been shown to cause disease in humans. XMRV was detectable in the peripheral blood mononuclear cells (PBMCs) and plasma of individuals diagnosed with CFS (Lombardi et al., 2009). After this report was published there was a great deal of uncertainty surrounding this emergent virus and its involvement in the etiology of CFS. The uncertainty was, in part, due to CFS being a complex, poorly understood multi-system disorder with different disease criteria used for its diagnosis. CFS, also known as Myalgic Encephalomyelitis (ME), is a debilitating disease of unknown origin that is estimated to affect 17 million people worldwide. The initial report connecting XMRV to prostate cancers and CFS garnered significant media and scientific interest since it provided a potential Susie ElSaadany2**, Tamer Oraby1 * Daniel Krewski1, 4 and Peter R. Ganz5 1McLaughlin Centre for Population Health Risk Assessment, Institute of Population Health, University of Ottawa, Ontario, Canada 2Blood Safety Surveillance and Health Care Acquired Infections Division, Centre for Communicable Diseases and Infection Control, Public Health Agency of Canada, Ottawa, Ontario, Canada 3Aspinall and Associates, Cleveland House, High Street, and Earth Sciences, Bristol University, Bristol, United Kingdom 4Department of Epidemiology and Community Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada 5Health Canada, Director’s Office, Ottawa, Ontario, Canada ** Corresponding Author , Marian Laderoute2 , Jun Wu2 , Willy Aspinall3 , www.intechopen.com 32 The Continuum of Health Risk Assessments explanation for the disease but also an avenue for possible therapeutic treatments since XMRV is known to be susceptible to some anti-retroviral drugs (Cohen, 2011).
    Book
    The Continuum of Health Risk Assessments
    URI
    http://library.oapen.org/handle/20.500.12657/32325
    Keywords
    case study; virus; case study; virus; Blood plasma; Blood-borne disease; Canada; Chronic fatigue syndrome; Polymerase chain reaction; Prostate cancer; Xenotropic murine leukemia virus-related virus
    DOI
    10.5772/38572
    OCN
    1030819683
    Publisher
    InTechOpen
    Publisher website
    https://www.intechopen.com/
    Publication date and place
    2012
    Grantor
    • FP7 Ideas: European Research Council - 228064 - VOLDIES - FP7 Research grant informationFind all documents
    Classification
    Science: general issues
    Public remark
    Relevant Wikipedia pages: Blood plasma - https://en.wikipedia.org/wiki/Blood_plasma; Blood-borne disease - https://en.wikipedia.org/wiki/Blood-borne_disease; Canada - https://en.wikipedia.org/wiki/Canada; Chronic fatigue syndrome - https://en.wikipedia.org/wiki/Chronic_fatigue_syndrome; Polymerase chain reaction - https://en.wikipedia.org/wiki/Polymerase_chain_reaction; Prostate cancer - https://en.wikipedia.org/wiki/Prostate_cancer; Virus - https://en.wikipedia.org/wiki/Virus; Xenotropic murine leukemia virus-related virus - https://en.wikipedia.org/wiki/Xenotropic_murine_leukemia_virus-related_virus
    Rights
    https://creativecommons.org/licenses/by/3.0/
    • Imported or submitted locally

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    • If not noted otherwise all contents are available under Attribution 4.0 International (CC BY 4.0)

    Credits

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    • This project received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No 683680, 810640, 871069 and 964352.

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