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dc.contributor.authorSchäfer, Thomas
dc.contributor.authorÖzalp, Veli C.
dc.contributor.authorÖzalp, Veli C.
dc.contributor.authorSchäfer, Thomas
dc.date.accessioned2019-10-04 14:28:10
dc.date.accessioned2020-04-01T14:07:00Z
dc.date.accessioned2016-08-01 23:55
dc.date.accessioned2019-10-04 14:28:10
dc.date.accessioned2020-04-01T14:07:00Z
dc.date.accessioned2016-12-31 23:55:55
dc.date.accessioned2019-10-04 14:28:10
dc.date.accessioned2020-04-01T14:07:00Z
dc.date.available2020-04-01T14:07:00Z
dc.date.issued2012
dc.identifier612587
dc.identifier.urihttp://library.oapen.org/handle/20.500.12657/32346
dc.description.abstractDrug delivery systems traditionally relied on passive diffusion mechanisms for targeting and releasing of therapeutically active molecules. The major problems associated with traditional delivery are poor specificity and dose-limited toxicity. Nanoparticles have found applicability in the development of novel drug delivery systems by easily overcoming toxicity problem. However, specificity of delivery has remained as a challenge. Developments in the methods of reaching to targeted tissue have lead to new and improved drug delivery platforms. Recently, active targeting has been incorporated by cell specific ligands such as antibodies, lectins, growth factor receptors. More recently, aptamers gained popularity in construction of novel actively targeted drug delivery systems (Ozalp et al., 2011). Considerable proportions of aptamer-based delivery systems have been incorporated to a variety of nanomaterials in order to improve their specific targeting properties (Chen et al., 2011; Zhou et al., 2011).
dc.languageEnglish
dc.subject.classificationbic Book Industry Communication::P Mathematics & science::PD Science: general issues
dc.subject.otherdrug delivery
dc.subject.othernanoparticles
dc.subject.otherdrug delivery
dc.subject.othernanoparticles
dc.subject.otherAptamer
dc.subject.otherProtein
dc.titleChapter 7 Aptamer-Nanoparticle Bioconjugates for Drug Delivery
dc.typechapter
oapen.identifier.doi10.5772/35188
oapen.relation.isPublishedBy09f6769d-48ed-467d-b150-4cf2680656a1
virtual.oapen_relation_isPublishedBy.publisher_nameInTechOpen
virtual.oapen_relation_isPublishedBy.publisher_websitehttps://www.intechopen.com/
oapen.relation.isPartOfBook3b2ebb32-419e-468f-b007-0649f0e5b9d9
virtual.oapen_relation_isPartOfBook.dc_titleThe Delivery of Nanoparticles
oapen.relation.isFundedBy7292b17b-f01a-4016-94d3-d7fb5ef9fb79
virtual.oapen_relation_isFundedBy.grantor_name FP7 Ideas: European Research Council
oapen.collectionEuropean Research Council (ERC)
oapen.chapternumber1
oapen.grant.number209842
oapen.grant.acronymMATRIX
oapen.grant.programFP7
oapen.remark.publicRelevant Wikipedia pages: Aptamer - https://en.wikipedia.org/wiki/Aptamer; Drug delivery - https://en.wikipedia.org/wiki/Drug_delivery; Nanoparticle - https://en.wikipedia.org/wiki/Nanoparticle; Protein - https://en.wikipedia.org/wiki/Protein


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