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dc.contributor.authorRonchi, Giulia
dc.contributor.authorShahar, Abraham
dc.contributor.authorRochkind, Shimon
dc.contributor.authorReider, Evgeniy
dc.contributor.authorBitan, Yifat
dc.contributor.authorGeuna, Stefano
dc.contributor.authorViano, Nicoletta
dc.contributor.authorKoren, Akiva
dc.contributor.authorMandelbaum-Livnat, Mira M.
dc.contributor.authorMorano, Michela
dc.contributor.authorZiv-Polat, Ofra
dc.contributor.authorBiron, Tali
dc.date.accessioned2021-06-02T10:09:29Z
dc.date.available2021-06-02T10:09:29Z
dc.date.issued2017
dc.identifierONIX_20210602_10.5772/intechopen.69882_323
dc.identifier.urihttps://library.oapen.org/handle/20.500.12657/49209
dc.description.abstractThe repair of peripheral nerve traumatic lesions still represents a major cause of permanent motor and sensory impairment. In case of substance loss, a nerve guide should be used to bridge the proximal with the distal stump of the severed nerve. The effectiveness of hollow nerve guides is limited by the delay of axonal growth due to the absence of a regeneration substrate inside the conduit. To fasten up nerve regeneration, nerve guides should thus be enriched by a luminal filler. In this study, we investigated, in a 12-mm rat sciatic nerve defect experimental model, the effectiveness of chitosan-based conduits of different acetylation filled either with a hyaluronic acid gel (NVR gel) or with a magnetic fibrin hydrogel, in comparison with traditional autografts. Results showed that all types of artificial nerve conduits led to functional recovery not significantly different from autografts. By contrast, morphological and morphometrical analyses showed that the best results among nerve guides were found in medium degree of acetylation (DAII: ∼5%) chitosan conduits enriched with the NVR gel.
dc.languageEnglish
dc.subject.classificationbic Book Industry Communication::M Medicine::MQ Nursing & ancillary services::MQW Biomedical engineering
dc.subject.otherperipheral nerve injury, chitosan guidance conduit, conduit acetylation, hyaluronic acid gel, magnetic fibrin hydrogel
dc.titleChapter Peripheral Nerve Reconstruction Using Enriched Chitosan Conduits
dc.typechapter
oapen.identifier.doi10.5772/intechopen.69882
oapen.relation.isPublishedBy09f6769d-48ed-467d-b150-4cf2680656a1
oapen.relation.isFundedByFP7-HEALTH-2011-two-stage
oapen.grant.number278612
oapen.grant.acronymBIOHYBRID


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