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dc.contributor.authorHolzgang, Melanie
dc.contributor.authorEigl, Benjamin
dc.contributor.authorErdem, Suna
dc.contributor.authorGloor, Beat
dc.contributor.authorWorni, Mathias
dc.date.accessioned2021-06-02T10:10:46Z
dc.date.available2021-06-02T10:10:46Z
dc.date.issued2018
dc.identifierONIX_20210602_10.5772/intechopen.75737_373
dc.identifier.urihttps://library.oapen.org/handle/20.500.12657/49259
dc.description.abstractPancreatic cancer is the deadliest of the gastrointestinal tract with 5-year survival rates of less than 5%. Given common asymptomatic early disease course, most patients (50%) present with an already metastatic disease, while only 20% can undergo potentially curative resection. The remaining 30% present with locally advanced disease, defined as extended vascular encasement, where the risk of surgical therapy often outweighs its benefits. Traditional thermal local ablative modalities (RFA, MWA, or cryotherapy) have the disadvantage that they are not applicable in proximity to vital vascular structures, which are abundant in the peripancreatic region. Irreversible electroporation (IRE) is an emerging non-thermal alternative that induces apoptosis of tumor cells by the delivery of short repetitive impulses of high-voltage electric current. Given its mostly non-thermal modality, IRE is not hampered by a heat-sink effect and is applicable with little risk around vascular structures, bile and pancreatic ducts. Recent research suggests that local tumor destruction through IRE improves overall survival, progression-free survival and quality of life in patients with locally advanced pancreatic cancer.
dc.languageEnglish
dc.subject.classificationbic Book Industry Communication::M Medicine::MB Medicine: general issues
dc.subject.otherlocally advanced pancreatic cancer, borderline resectable pancreatic cancer, irreversible electroporation, local tumor destruction, apoptosis, overall survival
dc.titleChapter Irreversible electroporation in pancreatic cancer
dc.typechapter
oapen.identifier.doi10.5772/intechopen.75737
oapen.relation.isPublishedBy09f6769d-48ed-467d-b150-4cf2680656a1
oapen.relation.isFundedByH2020-MSCA-ITN-2016
oapen.grant.number722068
oapen.grant.acronymHiPerNav


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