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dc.contributor.authorSchubert, Nicole
dc.contributor.authorAxer, Markus
dc.contributor.authorPietrzyk, Uwe
dc.contributor.authorAmunts, Katrin
dc.date.accessioned2021-06-02T10:10:53Z
dc.date.available2021-06-02T10:10:53Z
dc.date.issued2018
dc.identifierONIX_20210602_10.5772/intechopen.72532_378
dc.identifier.urihttps://library.oapen.org/handle/20.500.12657/49264
dc.description.abstract3D polarized light imaging (3D-PLI) is a neuroimaging technique that has recently opened up new avenues to study the complex architecture of nerve fibers in postmortem brains at microscopic scales. In a specific voxel-based analysis, each voxel is assigned a single 3D fiber orientation vector. This leads to comprehensive 3D vector fields. In order to inspect and analyze such high-resolution fiber orientation vector field, also in combination with complementary microscopy measurements, appropriate visualization techniques are essential to overcome several challenges, such as the massive data sizes, the large amount of both unique and redundant information at different scales, or the occlusion issues of inner structures by outer layers. Here, we introduce a comprehensive software tool that is able to visualize all information of a typical 3D-PLI dataset in an adequate and sophisticated manner. This includes the visualization of (i) anatomic structural and fiber architectonic data in one representation, (ii) a large-scale fiber orientation vector field, and (iii) a clustered version of the field. Alignment of a 3D-PLI dataset to an appropriate brain atlas provides expert-based delineation, segmentation, and, ultimately, visualization of selected anatomical structures. By means of these techniques, a detailed analysis of the complex fiber architecture in 3D is feasible.
dc.languageEnglish
dc.subject.classificationthema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciencesen_US
dc.subject.otherpolarized light imaging, scientific visualization, neuroinformatics, neuroimaging and fiber architecture
dc.titleChapter 3D Polarized Light Imaging Portrayed: Visualization of Fiber Architecture Derived from 3D-PLI
dc.typechapter
oapen.identifier.doi10.5772/intechopen.72532
oapen.relation.isPublishedBy09f6769d-48ed-467d-b150-4cf2680656a1
oapen.relation.isFundedByf1209042-b1d5-45a6-82b3-225d50f736ca
oapen.grant.number785907
oapen.grant.number720270
oapen.grant.acronymHBP SGA2
oapen.grant.acronymHBP SGA1


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