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dc.contributor.authorNombela, Ivan
dc.contributor.authorChico, Veronica
dc.contributor.authorPuente-Marin, Sara
dc.contributor.authorOrtega-Villaizan, M.
dc.date.accessioned2021-06-02T10:12:02Z
dc.date.available2021-06-02T10:12:02Z
dc.date.issued2019
dc.identifierONIX_20210602_10.5772/intechopen.80545_430
dc.identifier.urihttps://library.oapen.org/handle/20.500.12657/49316
dc.description.abstractIt has recently come to light that nucleated red blood cells (RBCs) of fish, amphibians, reptiles and birds are multifunctional cells, because in addition to being involved in gas exchange and transport, it has also been reported that they respond to pathogens by means of (i) phagocytosis, (ii) antigen presentation, (iii) production of cytokines and antimicrobial peptides, (iv) regulation of complement system, and (v) exerting paracrine molecular communication with other immune cells and modulating their functions. Similarly, human cord blood nucleated RBCs have been shown to exert a regulatory function in the innate immune response, by means of the suppression of the production of inflammatory cytokines. This chapter comprises the study of the implications of nucleated RBCs as mediators of both branches of immune system (innate and adaptive immune responses).
dc.languageEnglish
dc.subject.classificationbic Book Industry Communication::M Medicine::MM Other branches of medicine::MMF Pathology::MMFM Medical microbiology & virology
dc.subject.othernucleated red blood cells, erythrocytes, immune response, cytokines, antimicrobial peptides, virus, antigen presentation
dc.titleChapter Nucleated Red Blood Cells Contribute to the Host Immune Response Against Pathogens
dc.typechapter
oapen.identifier.doi10.5772/intechopen.80545
oapen.relation.isPublishedBy09f6769d-48ed-467d-b150-4cf2680656a1
oapen.relation.isFundedBy178e65b9-dd53-4922-b85c-0aaa74fce079
oapen.collectionEuropean Research Council (ERC)
oapen.grant.number639249
oapen.grant.acronymBLOODCELLSCROSSTALK


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