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dc.contributor.authorGonçalves, Moreno
dc.contributor.authorWysllas, de Freitas Oliveira
dc.contributor.authorCastelo, Branco
dc.contributor.authorLaura, Araújo
dc.contributor.authorMaria, Queiroz
dc.contributor.authorTavares, Donato
dc.contributor.authorJosé, da Silva Júnior
dc.contributor.authorThays, da Silva Rodrigues
dc.contributor.authorSousa, Silva
dc.date.accessioned2021-06-02T10:12:22Z
dc.date.available2021-06-02T10:12:22Z
dc.date.issued2019
dc.identifierONIX_20210602_10.5772/intechopen.84733_447
dc.identifier.urihttps://library.oapen.org/handle/20.500.12657/49333
dc.description.abstractThis chapter aims to present and discuss the main cell culture techniques used for the growth and maintenance of the different evolutionary forms of the protozoan Trypanosoma cruzi, the etiologic agent of the Chagas disease. Chagas disease is a neglected tropical disease endemic in several Latin American countries. Here, we intend to present the main difficulties, advantages, and disadvantages of using Trypanosoma cruzi cell culture in parasitic biology. Finally, we present the main research opportunities in the context of Trypanosoma cruzi parasitic biology using cell culture techniques, such as drug development, characterization of pharmacological targets, molecular markers for diagnosis, structural biology, and many other biomedical applications.
dc.languageEnglish
dc.subject.classificationbic Book Industry Communication::M Medicine::MM Other branches of medicine::MMF Pathology::MMFP Medical parasitology
dc.subject.otherTrypanosoma cruzi, Chagas disease, cell culture, in vitro assay, metacyclogenesis
dc.titleChapter Cell Culture and Maintenance of the Evolutionary Forms of Trypanosoma cruzi for Studies of Parasitic Biology
dc.typechapter
oapen.identifier.doi10.5772/intechopen.84733
oapen.relation.isPublishedBy09f6769d-48ed-467d-b150-4cf2680656a1
oapen.relation.isFundedByFP7 Health
oapen.grant.number305937
oapen.grant.acronymBERENICE


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