Chapter 15 Brain Tumors and the Lynch Syndrome

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Author(s)
Peltomäki, Päivi
Gylling, Annette
Collection
European Research Council (ERC)
Language
English
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Abstract
Lynch syndrome (LS) (MIM No. 120435-6), previously known as hereditary nonpolyposis colorectal cancer (HNPCC) (Boland, 2005), is an autosomal dominant disorder caused by germline mutation in one of the DNA mismatch repair (MMR) genes. LS is among the most prevalent cancer syndromes in man and is estimated to account for 1-6% of all colorectal cancers (Lynch & de la Chapelle, 2003).
Book
Management of CNS Tumors
URI
http://library.oapen.org/handle/20.500.12657/32348
Keywords
brain tumors; lynch syndrome; brain tumors; lynch syndrome; Colorectal cancer; DNA methylation; DNA mismatch repair; Gene; Glioblastoma; Glioma; Hereditary nonpolyposis colorectal cancer; Mutation; Neoplasm
DOI
10.5772/21293
OCN
1030821093
Publisher
InTechOpen
Publisher website
https://www.intechopen.com/
Publication date and place
2011
Grantor
Classification
Science: general issues
Public remark
Relevant Wikipedia pages: Brain tumor - https://en.wikipedia.org/wiki/Brain_tumor; Colorectal cancer - https://en.wikipedia.org/wiki/Colorectal_cancer; DNA methylation - https://en.wikipedia.org/wiki/DNA_methylation; DNA mismatch repair - https://en.wikipedia.org/wiki/DNA_mismatch_repair; Gene - https://en.wikipedia.org/wiki/Gene; Glioblastoma - https://en.wikipedia.org/wiki/Glioblastoma; Glioma - https://en.wikipedia.org/wiki/Glioma; Hereditary nonpolyposis colorectal cancer - https://en.wikipedia.org/wiki/Hereditary_nonpolyposis_colorectal_cancer; Mutation - https://en.wikipedia.org/wiki/Mutation; Neoplasm - https://en.wikipedia.org/wiki/Neoplasm
Rights
https://creativecommons.org/licenses/by-nc-sa/3.0/