Drug-Acceptor Interactions
Proposal review
Modeling Theoretical Tools to Test and Evaluate Experimental Equilibrium Effects
Abstract
Drug-Acceptor Interactions: Modeling theoretical tools to test and evaluate experimental equilibrium effects suggests novel theoretical tools to test and evaluate drug interactions seen with combinatorial drug therapy. The book provides an in-depth, yet controversial, exploration of existing tools for analysis of dose-response studies at equilibrium or steady state. The book is recommended reading for post-graduate students and researchers engaged in the study of systems biology, networks, and the pharmacodynamics of natural or industrial drugs, as well as for medical clinicians interested in drug application and combinatorial drug therapy. Even people without mathematical skills will be able to follow the pros and cons of reaction schemes and their related distribution equations. Chapter 9 is a hands-on guide for software to plot, fit and analyze one’s own data.
Keywords
Receptive Units; receptive; Fra Ct; unit; Reaction Scheme; reaction; MWC Model; scheme; Binding Sites; fra; Ternary Complex Model; binding; Receptor Conformations; sites; Lr Es; schild; Semi-log Plots; analysis; Secondary Binding Site; receptor; Schild Analysis; Equilibrium Dissociation Constants; Ant Agonist Concentration; Competitive Ant Agonism; ENaC; Inverse Agonists; Schild’s Plot; RR; Primary Ligand; Negative Co-operativityDOI
10.4324/9781315159782ISBN
9781351660587, 9789197707107, 9781315159782, 9781351660570, 9781351660563, 9781351660587OCN
1135847668Publisher
Taylor & FrancisPublisher website
https://taylorandfrancis.com/Publication date and place
2017Imprint
CRC PressClassification
Medical study and revision guides and reference material
Nursing and ancillary services