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    Drug-Acceptor Interactions

    Proposal review

    Modeling Theoretical Tools to Test and Evaluate Experimental Equilibrium Effects

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    Author(s)
    Bindslev, Niels
    Language
    English
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    Abstract
    Drug-Acceptor Interactions: Modeling theoretical tools to test and evaluate experimental equilibrium effects suggests novel theoretical tools to test and evaluate drug interactions seen with combinatorial drug therapy. The book provides an in-depth, yet controversial, exploration of existing tools for analysis of dose-response studies at equilibrium or steady state. The book is recommended reading for post-graduate students and researchers engaged in the study of systems biology, networks, and the pharmacodynamics of natural or industrial drugs, as well as for medical clinicians interested in drug application and combinatorial drug therapy. Even people without mathematical skills will be able to follow the pros and cons of reaction schemes and their related distribution equations. Chapter 9 is a hands-on guide for software to plot, fit and analyze one’s own data.
    URI
    https://library.oapen.org/handle/20.500.12657/101490
    Keywords
    Receptive Units; receptive; Fra Ct; unit; Reaction Scheme; reaction; MWC Model; scheme; Binding Sites; fra; Ternary Complex Model; binding; Receptor Conformations; sites; Lr Es; schild; Semi-log Plots; analysis; Secondary Binding Site; receptor; Schild Analysis; Equilibrium Dissociation Constants; Ant Agonist Concentration; Competitive Ant Agonism; ENaC; Inverse Agonists; Schild’s Plot; RR; Primary Ligand; Negative Co-operativity
    DOI
    10.4324/9781315159782
    ISBN
    9781351660587, 9789197707107, 9781315159782, 9781351660570, 9781351660563, 9781351660587
    OCN
    1135847668
    Publisher
    Taylor & Francis
    Publisher website
    https://taylorandfrancis.com/
    Publication date and place
    2017
    Imprint
    CRC Press
    Classification
    Medical study and revision guides and reference material
    Nursing and ancillary services
    Pages
    428
    Rights
    https://creativecommons.org/licenses/by-nc-nd/4.0/
    • Imported or submitted locally

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    License

    • If not noted otherwise all contents are available under Attribution 4.0 International (CC BY 4.0)

    Credits

    • logo EU
    • This project received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No 683680, 810640, 871069 and 964352.

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