Intersectionality—how gender intersects with race, class, and disability—has become central in understanding how girls experience discrimination. Although progress has been made in areas like primary education and vaccinations, many girls, especially in low-income countries, lack internet access, face high dropout rates, and bear a disproportionate load of unpaid care work. Conflict, climate change, and child marriage further threaten their futures. In Italy, despite educational achievements, women face a sharp decline in opportunities upon entering adulthood, with persistent wage gaps and low employment rates. Gender stereotypes persist in families, schools, and media. Financial literacy among girls is particularly low, limiting their future independence. These disparities call for urgent, gender-sensitive policies to ensure equal opportunities from childhood onward.