Chapter 15 Brain Tumors and the Lynch Syndrome
CollectionEuropean Research Council (ERC)
Lynch syndrome (LS) (MIM No. 120435-6), previously known as hereditary nonpolyposis colorectal cancer (HNPCC) (Boland, 2005), is an autosomal dominant disorder caused by germline mutation in one of the DNA mismatch repair (MMR) genes. LS is among the most prevalent cancer syndromes in man and is estimated to account for 1-6% of all colorectal cancers (Lynch & de la Chapelle, 2003).
Keywordsbrain tumors; lynch syndrome; brain tumors; lynch syndrome; Colorectal cancer; DNA methylation; DNA mismatch repair; Gene; Glioblastoma; Glioma; Hereditary nonpolyposis colorectal cancer; Mutation; Neoplasm
Publication date and place2011
Science: general issues