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    Chapter 3 Vitamin C Alimentation via SLC Solute Carriers

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    Author(s)
    Nydegger, Damien
    Gyimesi, Gergely
    Hediger, Matthias
    Language
    English
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    Abstract
    Although mortality rates from pneumonia and sepsis are decreasing in many parts of the world, the incidence of these conditions continues to rise, likely due to an increasingly ageing population. Case reports and observational studies indicate a strong association between vitamin C status and infectious conditions, with vitamin C deficiency predisposing individuals to infections, and conversely, infections precipitating a diminished vitamin C status. The requirements for vitamin C increase with the severity of the infectious condition, with gram amounts required to normalize the vitamin C status of critically ill patients. Over the past few years, there has been renewed interest in the role that vitamin C may play in severe infectious conditions. Vitamin C has a plethora of physiological effects, primarily due to its activity as a cofactor for a growing group of biosynthetic and regulatory enzymes, with the potential to regulate thousands of genes and cell signaling pathways. Small intervention studies have indicated that administration of gram doses of vitamin C to patients with pneumonia and sepsis improves organ function and potentially decreases mortality, although this remains to be confirmed in larger trials. The long-term quality of life outcomes of these patients also remains to be determined.
    Book
    Vitamin C
    URI
    https://library.oapen.org/handle/20.500.12657/40106
    Keywords
    antioxidants; ascorbic acid; infectious disease; intravenous ascorbate
    ISBN
    9780429442025
    Publisher
    Taylor & Francis
    Publisher website
    https://taylorandfrancis.com/
    Publication date and place
    2020
    Imprint
    CRC Press
    Classification
    Pharmacology
    Molecular biology
    Biology, life sciences
    Pages
    18
    Public remark
    3-8-2020 - No DOI registered in CrossRef for ISBN 9781138337992
    Rights
    https://creativecommons.org/licenses/by-nc-nd/4.0/
    • Imported or submitted locally

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    License

    • If not noted otherwise all contents are available under Attribution 4.0 International (CC BY 4.0)

    Credits

    • logo EU
    • This project received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No 683680, 810640, 871069 and 964352.

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