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    Human Challenge Studies in Endemic Settings

    Ethical and Regulatory Issues

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    Author(s)
    Jamrozik, Euzebiusz
    Selgelid, Michael J.
    Language
    English
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    Abstract
    This open access book provides an extensive review of ethical and regulatory issues related to human infection challenge studies, with a particular focus on the expansion of this type of research into endemic settings and/or low- and middle-income countries (LMICs). Human challenge studies (HCS) involve the intentional infection of research participants, and this type of research is rapidly increasing in frequency worldwide. HCS are widely considered to be an especially promising approach to vaccine development, including for pathogens endemic to LMICs. However, challenge studies are sometimes controversial and raise complex ethical issues, some of which are especially salient in endemic and/or LMIC settings. Informed by qualitative interviews with experts in infectious diseases and bioethics, this book highlights areas of ethical consensus and controversy concerning this kind of research. As the first volume to focus on ethical issues associated with human challenge studies, it sets the agenda for further work in this important area of global health research; contributes to current debates in research ethics; and aims to inform regulatory policy and research practice. Insofar as it focuses on HCS in (endemic) settings where diseases are present and/or widespread, much of the analysis provided here is directly relevant to HCS involving pandemic diseases including COVID19.
    URI
    https://library.oapen.org/handle/20.500.12657/41732
    Keywords
    Bioethics; Infectious Diseases; Vaccine; Development and Health; Moral Philosophy and Applied Ethics; Internal Medicine; Pharmacology; Development Studies; human challenge studies; Open Access; capacity building in low-income countries; capacity building in middle-income countries; malariotherapy; intentional infection; ethics of challenge studies; challenge studies in endemic settings; challenge studies and vulnerable populations; Falciparum malaria challenge studies in Africa; Infectious & contagious diseases; Immunology; Development studies
    DOI
    10.1007/978-3-030-41480-1
    Publisher
    Springer Nature
    Publisher website
    https://www.springernature.com/gp/products/books
    Publication date and place
    2021
    Imprint
    Springer
    Series
    SpringerBriefs in Ethics,
    Classification
    Bioethics
    Infectious and contagious diseases
    Immunology
    Development studies
    Pages
    134
    Rights
    http://creativecommons.org/licenses/by/4.0/
    • Imported or submitted locally

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    License

    • If not noted otherwise all contents are available under Attribution 4.0 International (CC BY 4.0)

    Credits

    • logo EU
    • This project received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No 683680, 810640, 871069 and 964352.

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