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    Chapter 5 Respiratory Syncytial Virus

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    Author(s)
    Jha, Akhilesh
    Jarvis, Hannah
    Fraser, Clementine
    Openshaw, Peter
    Collection
    Wellcome
    Language
    English
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    Abstract
    Respiratory syncytial virus (RSV) infection has an estimated global incidence of 33 million cases in children younger than 5 years, with 10% requiring hospital admission and up to 199,000 dying of the disease. There is growing evidence that severe infantile RSV bronchiolitis, a condition characterised by an inflammatory reaction to the virus, is associated with later childhood wheeze in some vulnerable children; however, a direct causal relationship with asthma has not yet been established. It is also increasingly recognised as a cause of morbidity and mortality in those with underlying airway disease, immunocompromise and frail elderly persons. Novel molecular based diagnostic tools are becoming established but treatment largely remains supportive, with palivizumab being the only licensed agent currently available for passive prophylaxis of selected pre-term infants. Whilst effective treatments remain elusive, there is optimism about the testing of novel antiviral drugs and the development of vaccines that may induce long-lasting immunity without the risk of disease augmentation.
    Book
    SARS, MERS and other Viral Lung Infections
    URI
    https://library.oapen.org/handle/20.500.12657/47857
    Keywords
    viral lung disease, RSV, paediatric infections, bronchiolitis, mucosal immunity
    ISBN
    9781849840705
    Publisher
    European Respiratory Society
    Publication date and place
    Sheffield, 2016
    Grantor
    • Wellcome Trust
    Classification
    Diseases and disorders
    Pages
    38
    Rights
    https://creativecommons.org/licenses/by-nc/4.0/
    • Imported or submitted locally

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    License

    • If not noted otherwise all contents are available under Attribution 4.0 International (CC BY 4.0)

    Credits

    • logo EU
    • This project received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No 683680, 810640, 871069 and 964352.

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