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dc.contributor.authorAerts, An
dc.contributor.authorRamadan, Raghda
dc.contributor.authorMohammedBenotmane, Abderrafi
dc.contributor.authorBaselet, Bjorn
dc.contributor.authorSonveaux, Pierre
dc.contributor.authorBaatout, Sarah
dc.date.accessioned2021-06-02T10:10:44Z
dc.date.available2021-06-02T10:10:44Z
dc.date.issued2018
dc.identifierONIX_20210602_10.5772/intechopen.72386_372
dc.identifier.urihttps://library.oapen.org/handle/20.500.12657/49258
dc.description.abstractAlong with the development of novel chemotherapeutic agents, radiation therapy has revolutionized the prognosis of patients with various cancers. However, with a longer life expectancy, radiation treatment-related comorbidity, like cardiovascular diseases (CVDs), becomes an issue for cancer survivors. In addition, exposure to X-rays for medical diagnostics is dramatically increasing at the present times. A pressing question is whether or not exposure to these very low doses can cause health damage. Below 0.5 gray (Gy), an increased risk cannot be evidenced by epidemiology alone, and in vitro and in vivo mechanistic studies focused on the elucidation of molecular signaling pathways are needed. Given the critical role of the endothelium in normal vascular functions, a complete understanding of radiation-induced endothelial dysfunction is crucial. In this way, the current radiation protection system could be refined if needed, making it possible to more accurately assess the cardiovascular risk in the low-dose region. Finally, radiation-induced CVD, like CVD in general, is a progressive disorder that may take years to decades to manifest. Therefore, experimental studies are warranted to fulfill the urgent need to identify noninvasive biomarkers for an early detection and potential interventions—together with a healthy lifestyle—that may prevent or mitigate these adverse effects.
dc.languageEnglish
dc.subject.classificationbic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJD Cardiovascular medicine
dc.subject.otherionizing radiation, radiation therapy, X-ray diagnostics, cardiovascular disease, atherosclerosis, endothelial dysfunction, inflammation, DNA damage, apoptosis, cell cycle, oxidative stress, mitochondrial dysfunction and metabolic changes, premature senescence, intercellular communication
dc.titleChapter Selected endothelial responses after ionizing radiation exposure
dc.typechapter
oapen.identifier.doi10.5772/intechopen.72386
oapen.relation.isPublishedBy09f6769d-48ed-467d-b150-4cf2680656a1
oapen.relation.isFundedByFP7-Fission-2011
oapen.grant.number295823
oapen.grant.number249689
oapen.grant.acronymPROCARDIO
oapen.grant.acronymDOREMI


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