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    Chapter Selected endothelial responses after ionizing radiation exposure

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    Author(s)
    Aerts, An
    Ramadan, Raghda
    MohammedBenotmane, Abderrafi
    Baselet, Bjorn
    Sonveaux, Pierre
    Baatout, Sarah
    Language
    English
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    Abstract
    Along with the development of novel chemotherapeutic agents, radiation therapy has revolutionized the prognosis of patients with various cancers. However, with a longer life expectancy, radiation treatment-related comorbidity, like cardiovascular diseases (CVDs), becomes an issue for cancer survivors. In addition, exposure to X-rays for medical diagnostics is dramatically increasing at the present times. A pressing question is whether or not exposure to these very low doses can cause health damage. Below 0.5 gray (Gy), an increased risk cannot be evidenced by epidemiology alone, and in vitro and in vivo mechanistic studies focused on the elucidation of molecular signaling pathways are needed. Given the critical role of the endothelium in normal vascular functions, a complete understanding of radiation-induced endothelial dysfunction is crucial. In this way, the current radiation protection system could be refined if needed, making it possible to more accurately assess the cardiovascular risk in the low-dose region. Finally, radiation-induced CVD, like CVD in general, is a progressive disorder that may take years to decades to manifest. Therefore, experimental studies are warranted to fulfill the urgent need to identify noninvasive biomarkers for an early detection and potential interventions—together with a healthy lifestyle—that may prevent or mitigate these adverse effects.
    URI
    https://library.oapen.org/handle/20.500.12657/49258
    Keywords
    ionizing radiation, radiation therapy, X-ray diagnostics, cardiovascular disease, atherosclerosis, endothelial dysfunction, inflammation, DNA damage, apoptosis, cell cycle, oxidative stress, mitochondrial dysfunction and metabolic changes, premature senescence, intercellular communication
    DOI
    10.5772/intechopen.72386
    Publisher
    InTechOpen
    Publisher website
    https://www.intechopen.com/
    Publication date and place
    2018
    Classification
    Cardiovascular medicine
    Rights
    https://creativecommons.org/licenses/by/3.0/
    • Imported or submitted locally

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    License

    • If not noted otherwise all contents are available under Attribution 4.0 International (CC BY 4.0)

    Credits

    • logo EU
    • This project received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No 683680, 810640, 871069 and 964352.

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