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dc.contributor.authorBernacchioni, Caterina
dc.date.accessioned2022-05-31T10:19:41Z
dc.date.available2022-05-31T10:19:41Z
dc.date.issued2012
dc.identifierONIX_20220531_9788866552192_314
dc.identifier.issn2612-8020
dc.identifier.urihttps://library.oapen.org/handle/20.500.12657/55030
dc.languageItalian
dc.relation.ispartofseriesPremio Tesi di Dottorato
dc.subject.classificationbic Book Industry Communication::M Medicine::MF Pre-clinical medicine: basic sciences
dc.subject.classificationbic Book Industry Communication::P Mathematics & science::PS Biology, life sciences::PSB Biochemistry
dc.subject.classificationbic Book Industry Communication::P Mathematics & science::PS Biology, life sciences::PSD Molecular biology
dc.titleSfingolipidi bioattivi e loro ruolo nell'azione biologica di fattori di crescita e citochine
dc.typebook
oapen.abstract.otherlanguageThis book gives an analysis of the role of the bioactive sphingolipids sphingosine-1-phosphate (S1P) and ceramide 1-phosphate (C1P) in the skeletal muscle. The enzyme that produces S1P, sphingosine kinase 1 (SK1) has proved crucial in the biological action of growth factors and cytokines involved in the inflammatory process that follows muscular damage. Indeed, in myoblasts the cytokine TGFβ exercises its fibrotic action through induction of the SK1/S1P axis. Furthermore, the PDGF growth factor, positive regulator of proliferation and motility, activates the enzyme SK1 and the transactivation of S1P1 inhibits the proliferation and induces the migration induced by the growth factor. Finally, the mitogenic role of C1P in myoblasts has been identified, characterizing the signalling pathways involved.
oapen.identifier.doi10.36253/978-88-6655-219-2
oapen.relation.isPublishedBybf65d21a-78e5-4ba2-983a-dbfa90962870
oapen.relation.isbn9788866552192
oapen.relation.isbn9788866552185
oapen.relation.isbn9788892735644
oapen.series.number26
oapen.pages152
oapen.place.publicationFirenze


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