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    Sfingolipidi bioattivi e loro ruolo nell'azione biologica di fattori di crescita e citochine

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    Author(s)
    Bernacchioni, Caterina cc
    Language
    Italian
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    Abstract
    This book gives an analysis of the role of the bioactive sphingolipids sphingosine-1-phosphate (S1P) and ceramide 1-phosphate (C1P) in the skeletal muscle. The enzyme that produces S1P, sphingosine kinase 1 (SK1) has proved crucial in the biological action of growth factors and cytokines involved in the inflammatory process that follows muscular damage. Indeed, in myoblasts the cytokine TGFβ exercises its fibrotic action through induction of the SK1/S1P axis. Furthermore, the PDGF growth factor, positive regulator of proliferation and motility, activates the enzyme SK1 and the transactivation of S1P1 inhibits the proliferation and induces the migration induced by the growth factor. Finally, the mitogenic role of C1P in myoblasts has been identified, characterizing the signalling pathways involved.
    URI
    https://library.oapen.org/handle/20.500.12657/55030
    DOI
    10.36253/978-88-6655-219-2
    ISBN
    9788866552192, 9788866552185, 9788892735644, 9788866552192
    Publisher
    Firenze University Press
    Publisher website
    https://www.fupress.com/
    Publication date and place
    Firenze, 2012
    Series
    Premio Tesi di Dottorato, 26
    Classification
    Pre-clinical medicine: basic sciences
    Biochemistry
    Molecular biology
    Pages
    152
    Rights
    https://creativecommons.org/licenses/by-nd/3.0/
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    Credits

    • logo Scoss
    • logo EU
    • logo Scoss
    • This project received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No 683680, 810640, 871069 and 964352.

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