The volume assumes that literature and its science are transdisciplinary and are fed by figures of thought, metaphors or models from other disciplines and, conversely, become a central place for innovative conceptualization. If such processes of literary descriptive vocabularies themselves become the object of consideration, then ruptures and sometimes controversies in the use of the metaphors that have often been transferred from the areas of organicity and technicality become increasingly apparent: organic and technical overlap, interfere, swap places. It is precisely these phenomena of border crossing in the metaphorical transfer of connections between the organic and the technical - which, in the face of the latest technologies and biopolitics, are more the "norm" than the exception - that the volume examines from a historiographical perspective from the Middle Ages to the present day. "Organitechnoscience" thus presents itself as a laboratory concept to trace literary and literary-theoretical operations of technical and organic interferences not only post, but also ante digitization and to question their knowledge-political dimensions.