Logo Oapen
  • Search
  • Join
    • Deposit
    • For Librarians
    • For Publishers
    • For Researchers
    • Funders
    • Resources
    • OAPEN
    • For Librarians
    • For Publishers
    • For Researchers
    • Funders
    • Resources
    • OAPEN
    View Item 
    •   OAPEN Home
    • View Item
    •   OAPEN Home
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Glutathione

    Proposal review

    Thumbnail
    Contributor(s)
    Flohé, Leopold (editor)
    Language
    English
    Show full item record
    Abstract
    This is the first serious attempt to synthesize all that became known of glutathione over the last three decades. The book contains an update of glutathione biosynthesis with special emphasis on its regulation in adaptive stress responses. Other chapters review glutathione transport systems and glutathione peroxidases and their differences in substrate specificities and localization. Further contributions center on the diversified roles of different glutathione--transferases and the roles of nitrosoglutathione and glutaredoxins - a subfamily of redoxins. The book closes with discussions of the analogous or homologous thiol metabolism in pathogens and the potential suitability of involved enzymes as drug targets. Key selling features: Summarizing the way glutathione is involved in stress responses Compiling the multiple ways glutathione affects inflammatory responses Disclosing how glutathione dampens programmed cell death such as ferroptosis Exploring the enigma of how enzymes accelerate glutathione-dependent processes Discussing how detoxification and redox regulation is mediated by glutathionylation Reviewing the ways glutaredoxins catalyze protein disulfide reduction Highlighting the medical impact of glutathione-related metabolic pathways Illustrating the role thiol metabolism of pathogens might play in drug discovery
    URI
    https://library.oapen.org/handle/20.500.12657/87680
    Keywords
    Protein Tyrosine Phosphatase 1B,LMW Thiol,GPx4 Expression,Active Site Cysteine,GPx1 mRNA,Thiol Disulfide Exchange Reactions,FeS Clusters,GCL Activity,GPx1 KO,GPx1 Activity,Mixed Disulfide,Iron Sulfur Clusters,Labile Iron Pool,Thiol Disulfide Oxidoreductases,GCLC Expression,Total GSH Content,GSH Transport,GSH Synthesis,BLM.,Iron Dependent Lipid Peroxidation,Mitochondrial GSH,Renal Proximal Tubular Cells,Free GSH,Dual Specificity Protein Phosphatase,PT,Biosynthesis,Adaptive Stress Response,Detoxification,Redox Reactions,Drug Discovery,Henry J. Forman,Hongqiao Zhang,Terrance J. Kavanagh,Lawrence H. Lash,Laura Orian,Giorgio Cozza,Matilde Maiorino,Stefano Toppo,Fulvio Ursini,Diane E. Handy,Joseph Loscalzo,Holger Steinbrenner,Lars-Oliver Klotz,Anna P. Kipp,Antonella Roveri,José Pedro,Friedmann Angeli,Valerian E. Kagan,Marcus Conrad,Yefim Manevich,Lutz Schomburg,Bengt Mannervik,Birgitta Sjödin,Kenneth D. Tew,Ralf Morgenstern,Jesper Z. Haeggström,Per-Johan Jakobsson,Leopold Flohé,Iain L. O. Buxton,Scott D. Barnett,Linda Liedgens,Marcel Deponte,Carsten Berndt,Anna Dorothee Engelke,Klaudia Lepka,Lars Bräutigam,Marcelo A. Comini,Martin Hugo,Madia Trujillo,Lucía Piacenza,Rafael Radi,Leonardo Astolfi Rosado,BrandPedre,Joris Messens,Quach Ngoc Tung,Nico Linzner,Vu Van Loi,Haike Antelmann
    DOI
    10.1201/9781351261760
    ISBN
    9780815365327, 9780367656997, 9781351261760
    Publisher
    Taylor & Francis
    Publisher website
    https://taylorandfrancis.com/
    Publication date and place
    2018
    Imprint
    CRC Press
    Series
    Oxidative Stress and Disease,
    Classification
    Pre-clinical medicine: basic sciences
    Cellular biology (cytology)
    Molecular biology
    Biology, life sciences
    Chapters in this book
    • Chapter 11 Glutathione Transferases
    Rights
    • Imported or submitted locally

    Browse

    All of OAPENSubjectsPublishersLanguagesCollections

    My Account

    LoginRegister

    Export

    Repository metadata
    Logo Oapen
    • For Librarians
    • For Publishers
    • For Researchers
    • Funders
    • Resources
    • OAPEN

    Newsletter

    • Subscribe to our newsletter
    • view our news archive

    Follow us on

    License

    • If not noted otherwise all contents are available under Attribution 4.0 International (CC BY 4.0)

    Credits

    • logo EU
    • This project received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No 683680, 810640, 871069 and 964352.

    OAPEN is based in the Netherlands, with its registered office in the National Library in The Hague.

    Director: Niels Stern

    Address:
    OAPEN Foundation
    Prins Willem-Alexanderhof 5
    2595 BE The Hague
    Postal address:
    OAPEN Foundation
    P.O. Box 90407
    2509 LK The Hague

    Websites:
    OAPEN Home: www.oapen.org
    OAPEN Library: library.oapen.org
    DOAB: www.doabooks.org

     

     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Differen formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    A logged-in user can export up to 15000 items. If you're not logged in, you can export no more than 500 items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.