Chapter 11 Glutathione Transferases
From the Test Tube to the Cell
Author(s)
Mannervik, Bengt
Sjödin, Birgitta
Language
EnglishAbstract
This is the first serious attempt to synthesize all that became known of glutathione over the last three decades. The book contains an update of glutathione biosynthesis with special emphasis on its regulation in adaptive stress responses. Other chapters review glutathione transport systems and glutathione peroxidases and their differences in substrate specificities and localization. Further contributions center on the diversified roles of different glutathione-<I>S</I>-transferases and the roles of nitrosoglutathione and glutaredoxins - a subfamily of redoxins. The book closes with discussions of the analogous or homologous thiol metabolism in pathogens and the potential suitability of involved enzymes as drug targets.
Key selling features:
Summarizing the way glutathione is involved in stress responses
Compiling the multiple ways glutathione affects inflammatory responses
Disclosing how glutathione dampens programmed cell death such as ferroptosis
Exploring the enigma of how enzymes accelerate glutathione-dependent processes
Discussing how detoxification and redox regulation is mediated by glutathionylation
Reviewing the ways glutaredoxins catalyze protein disulfide reduction
Highlighting the medical impact of glutathione-related metabolic pathways
Illustrating the role thiol metabolism of pathogens might play in drug discovery
Book
GlutathioneKeywords
MLCP Activation,MLCK Activity,Myosin Head,Airway Smooth Muscle,Actomyosin ATPase Activity,Cross-bridge Cycling,Protein Tyrosine Phosphatase 1B,Protein Tyrosine Phosphatase 1B,GSNOR,Soluble Guanylate Cyclase,Spontaneous PTL,Smooth Muscle,Cognate Kinase,Myometrial Quiescence,Pkg Action,RhoGEF,Cysteine Thiol,SMM,Smooth Muscle Contraction,Myosin Phosphatase,MLCP,Cap Protein,Cardiac Myosin,Regulatory Light Chain,CoxDOI
10.1201/9781351261760-14ISBN
9780815365327, 9780367656997, 9781351261760Publisher
Taylor & FrancisPublisher website
https://taylorandfrancis.com/Publication date and place
2018Imprint
CRC PressClassification
Pre-clinical medicine: basic sciences
Cellular biology (cytology)
Molecular biology
Biology, life sciences