Over the last 10 years, the Region of Tuscany, through the European Social Fund - Axis B Social Inclusion and fight against poverty, has developed a process/methodology to foster autonomy and accompany to work disadvantaged people and people with disability. It implements specific actions to contrast the phenomenon of poverty and social distress by providing a series of measures to facilitate work placement of people who for different reasons are at risk of exclusion from the labor market. The approach adopted consists of an integrated methodology that sees the recipients adhere to a customized project, prepared together with the Social Services, the local Employment Centers and public and private entities active in the field of interventions to combat poverty and social exclusion. Third Sector Entities play a key role in this framework.